It is estimated that 70% to 80%1 of small molecule drug candidates in development today can be classified as poorly water-soluble. Since poorly soluble drugs are difficult to formulate as tablets, formulation scientists are opting for two-piece, liquid-filled, hard-shell capsules as a solution.Liquid-filled, hard-shell capsules (LFHCs) were introduced in the early 1980s, as an alternative […]
